Difference time between Guyana and Sao Tome and Principe in hours, minutes, and seconds is [ -4 hours ] with gregorian date today is Thursday 1st of January 2026 in Guyanese local time, Where the time now in Guyana is 00:54 AM and the time now in Sao Tome and Principe is 04:54 AM in Sao Tomean local time and the time comparison between Co-operative Republic of Guyana and Sao Tome and Principe in greenwich time ( GMT ) where Guyana late for greenwich time ( GMT -04:00 ) while Sao Tome and Principe he has the same greenwich time ( GMT +00:00 ).