Difference time between Cayman Islands and Sao Tome and Principe in hours, minutes, and seconds is [ -5 hours ] with gregorian date today is Sunday 2nd of November 2025 in Caymanian local time, Where the time now in Cayman Islands is 19:26 PM and the time now in Sao Tome and Principe is 00:26 AM in Sao Tomean local time and the time comparison between Cayman Islands and Sao Tome and Principe in greenwich time ( GMT ) where Cayman Islands late for greenwich time ( GMT -05:00 ) while Sao Tome and Principe he has the same greenwich time ( GMT +00:00 ).